The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes
Identifieur interne : 000030 ( Main/Exploration ); précédent : 000029; suivant : 000031The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes
Auteurs : Lin Cui [République populaire de Chine] ; Li-Ping Zhao [République populaire de Chine] ; Jing-Ying Ye [République populaire de Chine] ; Lei Yang [République populaire de Chine] ; Yao Huang [République populaire de Chine] ; Xu-Pin Jiang [République populaire de Chine] ; Qiong Zhang [République populaire de Chine] ; Jie-Zhi Jia [République populaire de Chine] ; Dong-Xia Zhang [République populaire de Chine] ; Yuesheng Huang [République populaire de Chine]Source :
- Frontiers in Cell and Developmental Biology [ 2296-634X ] ; 2020.
Abstract
Lysosomal membrane permeabilization (LMP) has recently been recognized as an important cell death pathway in various cell types. However, studies regarding the correlation between LMP and cardiomyocyte death are scarce. Lysosomal membrane-associated protein 2 (Lamp2) is an important component of lysosomal membranes and is involved in both autophagy and LMP. In the present study, we found that the protein content of Lamp2 gradually decreased in response to oxygen, glucose and serum deprivation (OGD) treatment
Url:
DOI: 10.3389/fcell.2020.00031
PubMed: 32117965
PubMed Central: 7019187
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000529
- to stream Pmc, to step Curation: 000529
- to stream Pmc, to step Checkpoint: 000025
- to stream Ncbi, to step Merge: 000F84
- to stream Ncbi, to step Curation: 000F84
- to stream Ncbi, to step Checkpoint: 000F84
- to stream Main, to step Merge: 000030
- to stream Main, to step Curation: 000030
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes</title><author><name sortKey="Cui, Lin" sort="Cui, Lin" uniqKey="Cui L" first="Lin" last="Cui">Lin Cui</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Li Ping" sort="Zhao, Li Ping" uniqKey="Zhao L" first="Li-Ping" last="Zhao">Li-Ping Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Friendship Plastic Surgery Hospital, Nanjing Medical University</institution>,<addr-line>Nanjing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ye, Jing Ying" sort="Ye, Jing Ying" uniqKey="Ye J" first="Jing-Ying" last="Ye">Jing-Ying Ye</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Yao" sort="Huang, Yao" uniqKey="Huang Y" first="Yao" last="Huang">Yao Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Xu Pin" sort="Jiang, Xu Pin" uniqKey="Jiang X" first="Xu-Pin" last="Jiang">Xu-Pin Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Qiong" sort="Zhang, Qiong" uniqKey="Zhang Q" first="Qiong" last="Zhang">Qiong Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Jie Zhi" sort="Jia, Jie Zhi" uniqKey="Jia J" first="Jie-Zhi" last="Jia">Jie-Zhi Jia</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Dong Xia" sort="Zhang, Dong Xia" uniqKey="Zhang D" first="Dong-Xia" last="Zhang">Dong-Xia Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Yuesheng" sort="Huang, Yuesheng" uniqKey="Huang Y" first="Yuesheng" last="Huang">Yuesheng Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32117965</idno><idno type="pmc">7019187</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019187</idno><idno type="RBID">PMC:7019187</idno><idno type="doi">10.3389/fcell.2020.00031</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000529</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000529</idno><idno type="wicri:Area/Pmc/Curation">000529</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000529</idno><idno type="wicri:Area/Pmc/Checkpoint">000025</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000025</idno><idno type="wicri:Area/Ncbi/Merge">000F84</idno><idno type="wicri:Area/Ncbi/Curation">000F84</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F84</idno><idno type="wicri:Area/Main/Merge">000030</idno><idno type="wicri:Area/Main/Curation">000030</idno><idno type="wicri:Area/Main/Exploration">000030</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes</title><author><name sortKey="Cui, Lin" sort="Cui, Lin" uniqKey="Cui L" first="Lin" last="Cui">Lin Cui</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Li Ping" sort="Zhao, Li Ping" uniqKey="Zhao L" first="Li-Ping" last="Zhao">Li-Ping Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Friendship Plastic Surgery Hospital, Nanjing Medical University</institution>,<addr-line>Nanjing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ye, Jing Ying" sort="Ye, Jing Ying" uniqKey="Ye J" first="Jing-Ying" last="Ye">Jing-Ying Ye</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Yao" sort="Huang, Yao" uniqKey="Huang Y" first="Yao" last="Huang">Yao Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Xu Pin" sort="Jiang, Xu Pin" uniqKey="Jiang X" first="Xu-Pin" last="Jiang">Xu-Pin Jiang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Qiong" sort="Zhang, Qiong" uniqKey="Zhang Q" first="Qiong" last="Zhang">Qiong Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Jie Zhi" sort="Jia, Jie Zhi" uniqKey="Jia J" first="Jie-Zhi" last="Jia">Jie-Zhi Jia</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Dong Xia" sort="Zhang, Dong Xia" uniqKey="Zhang D" first="Dong-Xia" last="Zhang">Dong-Xia Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Yuesheng" sort="Huang, Yuesheng" uniqKey="Huang Y" first="Yuesheng" last="Huang">Yuesheng Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University)</institution>,<addr-line>Chongqing</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Cell and Developmental Biology</title><idno type="eISSN">2296-634X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lysosomal membrane permeabilization (LMP) has recently been recognized as an important cell death pathway in various cell types. However, studies regarding the correlation between LMP and cardiomyocyte death are scarce. Lysosomal membrane-associated protein 2 (Lamp2) is an important component of lysosomal membranes and is involved in both autophagy and LMP. In the present study, we found that the protein content of Lamp2 gradually decreased in response to oxygen, glucose and serum deprivation (OGD) treatment <italic>in vitro</italic>. To further elucidate its role in ischemic cardiomyocytes, particularly with respect to autophagy and LMP, we infected cardiomyocytes with adenovirus carrying full-length Lamp2 to restore its protein level in cells. We found that OGD treatment resulted in the occurrence of LMP and a decline in the viability of cardiomyocytes, which were remarkably reversed by Lamp2 restoration. Exogenous expression of Lamp2 also significantly alleviated the autophagic flux blockade induced by OGD treatment by promoting the trafficking of cathepsin B (Cat B) and cathepsin D (Cat D). Through drug intervention and gene regulation to alleviate and exacerbate autophagic flux blockade respectively, we found that impaired autophagic flux in response to ischemic injury contributed to the occurrence of LMP in cardiomyocytes. In conclusion, our present data suggest that Lamp2 overexpression can improve autophagic flux blockade probably by promoting the trafficking of cathepsins and consequently conferring cardiomyocyte resistance against lysosomal cell death (LCD) that is induced by ischemic injury. These results may indicate a new therapeutic target for ischemic heart damage.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cenacchi, G" uniqKey="Cenacchi G">G. Cenacchi</name></author><author><name sortKey="Papa, V" uniqKey="Papa V">V. Papa</name></author><author><name sortKey="Pegoraro, V" uniqKey="Pegoraro V">V. Pegoraro</name></author><author><name sortKey="Marozzo, R" uniqKey="Marozzo R">R. Marozzo</name></author><author><name sortKey="Fanin, M" uniqKey="Fanin M">M. Fanin</name></author><author><name sortKey="Angelini, C" uniqKey="Angelini C">C. Angelini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clerc, P" uniqKey="Clerc P">P. Clerc</name></author><author><name sortKey="Jeanjean, P" uniqKey="Jeanjean P">P. Jeanjean</name></author><author><name sortKey="Hallali, N" uniqKey="Hallali N">N. Hallali</name></author><author><name sortKey="Gougeon, M" uniqKey="Gougeon M">M. Gougeon</name></author><author><name sortKey="Pipy, B" uniqKey="Pipy B">B. Pipy</name></author><author><name sortKey="Carrey, J" uniqKey="Carrey J">J. Carrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damaghi, M" uniqKey="Damaghi M">M. Damaghi</name></author><author><name sortKey="Tafreshi, N K" uniqKey="Tafreshi N">N. K. Tafreshi</name></author><author><name sortKey="Lloyd, M C" uniqKey="Lloyd M">M. C. Lloyd</name></author><author><name sortKey="Sprung, R" uniqKey="Sprung R">R. Sprung</name></author><author><name sortKey="Estrella, V" uniqKey="Estrella V">V. Estrella</name></author><author><name sortKey="Wojtkowiak, J W" uniqKey="Wojtkowiak J">J. W. Wojtkowiak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Duve, C" uniqKey="De Duve C">C. de Duve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diaz, E" uniqKey="Diaz E">E. Diaz</name></author><author><name sortKey="Pfeffer, S R" uniqKey="Pfeffer S">S. R. Pfeffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dikic, I" uniqKey="Dikic I">I. Dikic</name></author><author><name sortKey="Elazar, Z" uniqKey="Elazar Z">Z. Elazar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duke, J M" uniqKey="Duke J">J. M. Duke</name></author><author><name sortKey="Randall, S M" uniqKey="Randall S">S. M. Randall</name></author><author><name sortKey="Fear, M W" uniqKey="Fear M">M. W. Fear</name></author><author><name sortKey="Boyd, J H" uniqKey="Boyd J">J. H. Boyd</name></author><author><name sortKey="Rea, S" uniqKey="Rea S">S. Rea</name></author><author><name sortKey="Wood, F M" uniqKey="Wood F">F. M. Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edtinger, K" uniqKey="Edtinger K">K. Edtinger</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name></author><author><name sortKey="Uehara, H" uniqKey="Uehara H">H. Uehara</name></author><author><name sortKey="Tullius, S G" uniqKey="Tullius S">S. G. Tullius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Endo, Y" uniqKey="Endo Y">Y. Endo</name></author><author><name sortKey="Furuta, A" uniqKey="Furuta A">A. Furuta</name></author><author><name sortKey="Nishino, I" uniqKey="Nishino I">I. Nishino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eskelinen, E L" uniqKey="Eskelinen E">E. L. Eskelinen</name></author><author><name sortKey="Illert, A L" uniqKey="Illert A">A. L. Illert</name></author><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y. Tanaka</name></author><author><name sortKey="Schwarzmann, G" uniqKey="Schwarzmann G">G. Schwarzmann</name></author><author><name sortKey="Blanz, J" uniqKey="Blanz J">J. Blanz</name></author><author><name sortKey="Von Figura, K" uniqKey="Von Figura K">K. Von Figura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabande Rodriguez, E" uniqKey="Gabande Rodriguez E">E. Gabande-Rodriguez</name></author><author><name sortKey="Boya, P" uniqKey="Boya P">P. Boya</name></author><author><name sortKey="Labrador, V" uniqKey="Labrador V">V. Labrador</name></author><author><name sortKey="Dotti, C G" uniqKey="Dotti C">C. G. Dotti</name></author><author><name sortKey="Ledesma, M D" uniqKey="Ledesma M">M. D. Ledesma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaidt, M M" uniqKey="Gaidt M">M. M. Gaidt</name></author><author><name sortKey="Ebert, T S" uniqKey="Ebert T">T. S. Ebert</name></author><author><name sortKey="Chauhan, D" uniqKey="Chauhan D">D. Chauhan</name></author><author><name sortKey="Ramshorn, K" uniqKey="Ramshorn K">K. Ramshorn</name></author><author><name sortKey="Pinci, F" uniqKey="Pinci F">F. Pinci</name></author><author><name sortKey="Zuber, S" uniqKey="Zuber S">S. Zuber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ganitkevich, V" uniqKey="Ganitkevich V">V. Ganitkevich</name></author><author><name sortKey="Reil, S" uniqKey="Reil S">S. Reil</name></author><author><name sortKey="Schwethelm, B" uniqKey="Schwethelm B">B. Schwethelm</name></author><author><name sortKey="Schroeter, T" uniqKey="Schroeter T">T. Schroeter</name></author><author><name sortKey="Benndorf, K" uniqKey="Benndorf K">K. Benndorf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geronimo Olvera, C" uniqKey="Geronimo Olvera C">C. Geronimo-Olvera</name></author><author><name sortKey="Montiel, T" uniqKey="Montiel T">T. Montiel</name></author><author><name sortKey="Rincon Heredia, R" uniqKey="Rincon Heredia R">R. Rincon-Heredia</name></author><author><name sortKey="Castro Obregon, S" uniqKey="Castro Obregon S">S. Castro-Obregon</name></author><author><name sortKey="Massieu, L" uniqKey="Massieu L">L. Massieu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, S" uniqKey="Giuliano S">S. Giuliano</name></author><author><name sortKey="Cormerais, Y" uniqKey="Cormerais Y">Y. Cormerais</name></author><author><name sortKey="Dufies, M" uniqKey="Dufies M">M. Dufies</name></author><author><name sortKey="Grepin, R" uniqKey="Grepin R">R. Grepin</name></author><author><name sortKey="Colosetti, P" uniqKey="Colosetti P">P. Colosetti</name></author><author><name sortKey="Belaid, A" uniqKey="Belaid A">A. Belaid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez Sintes, R" uniqKey="Gomez Sintes R">R. Gomez-Sintes</name></author><author><name sortKey="Ledesma, M D" uniqKey="Ledesma M">M. D. Ledesma</name></author><author><name sortKey="Boya, P" uniqKey="Boya P">P. Boya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez, P" uniqKey="Gonzalez P">P. Gonzalez</name></author><author><name sortKey="Mader, I" uniqKey="Mader I">I. Mader</name></author><author><name sortKey="Tchoghandjian, A" uniqKey="Tchoghandjian A">A. Tchoghandjian</name></author><author><name sortKey="Enzenmuller, S" uniqKey="Enzenmuller S">S. Enzenmuller</name></author><author><name sortKey="Cristofanon, S" uniqKey="Cristofanon S">S. Cristofanon</name></author><author><name sortKey="Basit, F" uniqKey="Basit F">F. Basit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, J Y" uniqKey="Hu J">J. Y. Hu</name></author><author><name sortKey="Chu, Z G" uniqKey="Chu Z">Z. G. Chu</name></author><author><name sortKey="Han, J" uniqKey="Han J">J. Han</name></author><author><name sortKey="Dang, Y M" uniqKey="Dang Y">Y. M. Dang</name></author><author><name sortKey="Yan, H" uniqKey="Yan H">H. Yan</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, L" uniqKey="Huang L">L. Huang</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y. Luo</name></author><author><name sortKey="Sun, X" uniqKey="Sun X">X. Sun</name></author><author><name sortKey="Ju, H" uniqKey="Ju H">H. Ju</name></author><author><name sortKey="Tian, J" uniqKey="Tian J">J. Tian</name></author><author><name sortKey="Yu, B Y" uniqKey="Yu B">B. Y. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hubert, V" uniqKey="Hubert V">V. Hubert</name></author><author><name sortKey="Peschel, A" uniqKey="Peschel A">A. Peschel</name></author><author><name sortKey="Langer, B" uniqKey="Langer B">B. Langer</name></author><author><name sortKey="Groger, M" uniqKey="Groger M">M. Gröger</name></author><author><name sortKey="Rees, A" uniqKey="Rees A">A. Rees</name></author><author><name sortKey="Kain, R" uniqKey="Kain R">R. Kain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Issa, A R" uniqKey="Issa A">A. R. Issa</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J. Sun</name></author><author><name sortKey="Petitgas, C" uniqKey="Petitgas C">C. Petitgas</name></author><author><name sortKey="Mesquita, A" uniqKey="Mesquita A">A. Mesquita</name></author><author><name sortKey="Dulac, A" uniqKey="Dulac A">A. Dulac</name></author><author><name sortKey="Robin, M" uniqKey="Robin M">M. Robin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaattela, M" uniqKey="Jaattela M">M. Jaattela</name></author><author><name sortKey="Nylandsted, J" uniqKey="Nylandsted J">J. Nylandsted</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jian, Z" uniqKey="Jian Z">Z. Jian</name></author><author><name sortKey="Liang, B" uniqKey="Liang B">B. Liang</name></author><author><name sortKey="Pan, X" uniqKey="Pan X">X. Pan</name></author><author><name sortKey="Xu, G" uniqKey="Xu G">G. Xu</name></author><author><name sortKey="Guo, S S" uniqKey="Guo S">S. S. Guo</name></author><author><name sortKey="Li, T" uniqKey="Li T">T. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name></author><author><name sortKey="Acharya, C" uniqKey="Acharya C">C. Acharya</name></author><author><name sortKey="An, G" uniqKey="An G">G. An</name></author><author><name sortKey="Zhong, M" uniqKey="Zhong M">M. Zhong</name></author><author><name sortKey="Feng, X" uniqKey="Feng X">X. Feng</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Law, C Y" uniqKey="Law C">C. Y. Law</name></author><author><name sortKey="Siu, C W" uniqKey="Siu C">C. W. Siu</name></author><author><name sortKey="Fan, K" uniqKey="Fan K">K. Fan</name></author><author><name sortKey="Lai, W H" uniqKey="Lai W">W. H. Lai</name></author><author><name sortKey="Au, K W" uniqKey="Au K">K. W. Au</name></author><author><name sortKey="Lau, Y M" uniqKey="Lau Y">Y. M. Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, S C" uniqKey="Lin S">S. C. Lin</name></author><author><name sortKey="Hardie, D G" uniqKey="Hardie D">D. G. Hardie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipton, P" uniqKey="Lipton P">P. Lipton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lovejoy, D B" uniqKey="Lovejoy D">D. B. Lovejoy</name></author><author><name sortKey="Jansson, P J" uniqKey="Jansson P">P. J. Jansson</name></author><author><name sortKey="Brunk, U T" uniqKey="Brunk U">U. T. Brunk</name></author><author><name sortKey="Wong, J" uniqKey="Wong J">J. Wong</name></author><author><name sortKey="Ponka, P" uniqKey="Ponka P">P. Ponka</name></author><author><name sortKey="Richardson, D R" uniqKey="Richardson D">D. R. Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, X" uniqKey="Ma X">X. Ma</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Foyil, S R" uniqKey="Foyil S">S. R. Foyil</name></author><author><name sortKey="Godar, R J" uniqKey="Godar R">R. J. Godar</name></author><author><name sortKey="Weinheimer, C J" uniqKey="Weinheimer C">C. J. Weinheimer</name></author><author><name sortKey="Hill, J A" uniqKey="Hill J">J. A. Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maejima, I" uniqKey="Maejima I">I. Maejima</name></author><author><name sortKey="Takahashi, A" uniqKey="Takahashi A">A. Takahashi</name></author><author><name sortKey="Omori, H" uniqKey="Omori H">H. Omori</name></author><author><name sortKey="Kimura, T" uniqKey="Kimura T">T. Kimura</name></author><author><name sortKey="Takabatake, Y" uniqKey="Takabatake Y">Y. Takabatake</name></author><author><name sortKey="Saitoh, T" uniqKey="Saitoh T">T. Saitoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mai, T T" uniqKey="Mai T">T. T. Mai</name></author><author><name sortKey="Hamai, A" uniqKey="Hamai A">A. Hamai</name></author><author><name sortKey="Hienzsch, A" uniqKey="Hienzsch A">A. Hienzsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malet, J K" uniqKey="Malet J">J. K. Malet</name></author><author><name sortKey="Cossart, P" uniqKey="Cossart P">P. Cossart</name></author><author><name sortKey="Ribet, D" uniqKey="Ribet D">D. Ribet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milkereit, R" uniqKey="Milkereit R">R. Milkereit</name></author><author><name sortKey="Persaud, A" uniqKey="Persaud A">A. Persaud</name></author><author><name sortKey="Vanoaica, L" uniqKey="Vanoaica L">L. Vanoaica</name></author><author><name sortKey="Guetg, A" uniqKey="Guetg A">A. Guetg</name></author><author><name sortKey="Verrey, F" uniqKey="Verrey F">F. Verrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N. Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nair, P" uniqKey="Nair P">P. Nair</name></author><author><name sortKey="Schaub, B E" uniqKey="Schaub B">B. E. Schaub</name></author><author><name sortKey="Rohrer, J" uniqKey="Rohrer J">J. Rohrer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ono, K" uniqKey="Ono K">K. Ono</name></author><author><name sortKey="Kim, S O" uniqKey="Kim S">S. O. Kim</name></author><author><name sortKey="Han, J" uniqKey="Han J">J. Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasdois, P" uniqKey="Pasdois P">P. Pasdois</name></author><author><name sortKey="Parker, J E" uniqKey="Parker J">J. E. Parker</name></author><author><name sortKey="Halestrap, A P" uniqKey="Halestrap A">A. P. Halestrap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pei, H F" uniqKey="Pei H">H. F. Pei</name></author><author><name sortKey="Hou, J N" uniqKey="Hou J">J. N. Hou</name></author><author><name sortKey="Wei, F P" uniqKey="Wei F">F. P. Wei</name></author><author><name sortKey="Xue, Q" uniqKey="Xue Q">Q. Xue</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Peng, C F" uniqKey="Peng C">C. F. Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, X" uniqKey="Qin X">X. Qin</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name></author><author><name sortKey="Xu, G" uniqKey="Xu G">G. Xu</name></author><author><name sortKey="Zou, Z" uniqKey="Zou Z">Z. Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Repnik, U" uniqKey="Repnik U">U. Repnik</name></author><author><name sortKey="Cesen, M H" uniqKey="Cesen M">M. H. Cesen</name></author><author><name sortKey="Turk, B" uniqKey="Turk B">B. Turk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rowland, T J" uniqKey="Rowland T">T. J. Rowland</name></author><author><name sortKey="Sweet, M E" uniqKey="Sweet M">M. E. Sweet</name></author><author><name sortKey="Mestroni, L" uniqKey="Mestroni L">L. Mestroni</name></author><author><name sortKey="Taylor, M R" uniqKey="Taylor M">M. R. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, S J" uniqKey="Roy S">S. J. Roy</name></author><author><name sortKey="Stanely Mainzen Prince, P" uniqKey="Stanely Mainzen Prince P">P. Stanely Mainzen Prince</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saha, T" uniqKey="Saha T">T. Saha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C. Settembre</name></author><author><name sortKey="Fraldi, A" uniqKey="Fraldi A">A. Fraldi</name></author><author><name sortKey="Medina, D L" uniqKey="Medina D">D. L. Medina</name></author><author><name sortKey="Ballabio, A" uniqKey="Ballabio A">A. Ballabio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skowyra, M L" uniqKey="Skowyra M">M. L. Skowyra</name></author><author><name sortKey="Schlesinger, P H" uniqKey="Schlesinger P">P. H. Schlesinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sugie, K" uniqKey="Sugie K">K. Sugie</name></author><author><name sortKey="Komaki, H" uniqKey="Komaki H">H. Komaki</name></author><author><name sortKey="Eura, N" uniqKey="Eura N">N. Eura</name></author><author><name sortKey="Shiota, T" uniqKey="Shiota T">T. Shiota</name></author><author><name sortKey="Onoue, K" uniqKey="Onoue K">K. Onoue</name></author><author><name sortKey="Tsukaguchi, H" uniqKey="Tsukaguchi H">H. Tsukaguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y. Tanaka</name></author><author><name sortKey="Guhde, G" uniqKey="Guhde G">G. Guhde</name></author><author><name sortKey="Suter, A" uniqKey="Suter A">A. Suter</name></author><author><name sortKey="Eskelinen, E L" uniqKey="Eskelinen E">E. L. Eskelinen</name></author><author><name sortKey="Hartmann, D" uniqKey="Hartmann D">D. Hartmann</name></author><author><name sortKey="Lullmann Rauch, R" uniqKey="Lullmann Rauch R">R. Lullmann-Rauch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tiwari, M" uniqKey="Tiwari M">M. Tiwari</name></author><author><name sortKey="Hemalatha, T" uniqKey="Hemalatha T">T. Hemalatha</name></author><author><name sortKey="Ganesan, K" uniqKey="Ganesan K">K. Ganesan</name></author><author><name sortKey="Nayeem, M" uniqKey="Nayeem M">M. Nayeem</name></author><author><name sortKey="Murali Manohar, B" uniqKey="Murali Manohar B">B. Murali Manohar</name></author><author><name sortKey="Balachandran, C" uniqKey="Balachandran C">C. Balachandran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiedmer, T" uniqKey="Wiedmer T">T. Wiedmer</name></author><author><name sortKey="Blank, A" uniqKey="Blank A">A. Blank</name></author><author><name sortKey="Pantasis, S" uniqKey="Pantasis S">S. Pantasis</name></author><author><name sortKey="Normand, L" uniqKey="Normand L">L. Normand</name></author><author><name sortKey="Bill, R" uniqKey="Bill R">R. Bill</name></author><author><name sortKey="Krebs, P" uniqKey="Krebs P">P. Krebs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Windelborn, J A" uniqKey="Windelborn J">J. A. Windelborn</name></author><author><name sortKey="Lipton, P" uniqKey="Lipton P">P. Lipton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author><author><name sortKey="Qin, Y" uniqKey="Qin Y">Y. Qin</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X. Zhu</name></author><author><name sortKey="Liu, D" uniqKey="Liu D">D. Liu</name></author><author><name sortKey="Chen, F" uniqKey="Chen F">F. Chen</name></author><author><name sortKey="Xu, S" uniqKey="Xu S">S. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamashima, T" uniqKey="Yamashima T">T. Yamashima</name></author><author><name sortKey="Oikawa, S" uniqKey="Oikawa S">S. Oikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, S Y" uniqKey="Yu S">S. Y. Yu</name></author><author><name sortKey="Dong, B" uniqKey="Dong B">B. Dong</name></author><author><name sortKey="Fang, Z F" uniqKey="Fang Z">Z. F. Fang</name></author><author><name sortKey="Hu, X Q" uniqKey="Hu X">X. Q. Hu</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Lak, B" uniqKey="Lak B">B. Lak</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Jokitalo, E" uniqKey="Jokitalo E">E. Jokitalo</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, X Y" uniqKey="Zhou X">X. Y. Zhou</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y. Luo</name></author><author><name sortKey="Zhu, Y M" uniqKey="Zhu Y">Y. M. Zhu</name></author><author><name sortKey="Liu, Z H" uniqKey="Liu Z">Z. H. Liu</name></author><author><name sortKey="Kent, T A" uniqKey="Kent T">T. A. Kent</name></author><author><name sortKey="Rong, J G" uniqKey="Rong J">J. G. Rong</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cui, Lin" sort="Cui, Lin" uniqKey="Cui L" first="Lin" last="Cui">Lin Cui</name></noRegion><name sortKey="Huang, Yao" sort="Huang, Yao" uniqKey="Huang Y" first="Yao" last="Huang">Yao Huang</name><name sortKey="Huang, Yuesheng" sort="Huang, Yuesheng" uniqKey="Huang Y" first="Yuesheng" last="Huang">Yuesheng Huang</name><name sortKey="Jia, Jie Zhi" sort="Jia, Jie Zhi" uniqKey="Jia J" first="Jie-Zhi" last="Jia">Jie-Zhi Jia</name><name sortKey="Jiang, Xu Pin" sort="Jiang, Xu Pin" uniqKey="Jiang X" first="Xu-Pin" last="Jiang">Xu-Pin Jiang</name><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name><name sortKey="Ye, Jing Ying" sort="Ye, Jing Ying" uniqKey="Ye J" first="Jing-Ying" last="Ye">Jing-Ying Ye</name><name sortKey="Zhang, Dong Xia" sort="Zhang, Dong Xia" uniqKey="Zhang D" first="Dong-Xia" last="Zhang">Dong-Xia Zhang</name><name sortKey="Zhang, Qiong" sort="Zhang, Qiong" uniqKey="Zhang Q" first="Qiong" last="Zhang">Qiong Zhang</name><name sortKey="Zhao, Li Ping" sort="Zhao, Li Ping" uniqKey="Zhao L" first="Li-Ping" last="Zhao">Li-Ping Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000030 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000030 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7019187
|texte= The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32117965" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |